期刊
GENES & DEVELOPMENT
卷 19, 期 20, 页码 2412-2417出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1353905
关键词
intestinal mucosa; developmental gene expression regulation; cell differentiation; Paneth cell; goblet cell; enteroendocrine cell
资金
- NICHD NIH HHS [P30 HD024064, P30 HD24064] Funding Source: Medline
- NIDCD NIH HHS [F32 DC005109, F32 DC5109] Funding Source: Medline
- NIDDK NIH HHS [T32 DK007664, F32 DK63747, P30 DK056338, F32 DK063747, P30 DK56338, T32 DK07664] Funding Source: Medline
Gfi1 is a transcriptional repressor implicated in lymphomagenesis, neutropenia, and hematopoietic development, as well as ear and lung development. Here, we demonstrate that Gfi1 functions downstream of Math1 in intestinal secretory lineage differentiation. Gfi1(-/-) mice lack Paneth cells, have fewer goblet cells, and supernumerary enteroendocrine cells. Gfi1(-/-) mice show gene expression changes consistent with this altered cell allocation. These data suggest that Gfi1 functions to select goblet/Paneth versus enteroendocrine progenitors. We propose a model of intestinal cell fate choice in which beta-catenin and Cdx function upstream of Math1, and lineage-specific genes such as Ngn3 act downstream of Gfi1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据