期刊
FEMS MICROBIOLOGY LETTERS
卷 251, 期 2, 页码 321-326出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.08.018
关键词
Streptococcus mutans; competence stimulating peptide; programmed cell death; mutans; biofilms
类别
资金
- NIDCR NIH HHS [U01-DE15018, R01 DE013965, R01 DE013230-0, T32 DE007296, R01 DE013230, R01-DE014757] Funding Source: Medline
Streptococcus mutans is considered one of the main causative agents of human dental caries. Cell-cell communication through two-component signal transduction systems (TCSTS) plays an important role in the pathogenesis of S. mutans. One of the S. mutans TCSTS, ComDE, controls both competence development and biofilm formation. In this study, we showed that addition of exogenous competence-stimulating peptide (CSP) beyond the levels necessary for competence inhibited the growth of S. mutans in a ComDE-dependent manner. We also demonstrated that further increases of CSP stopped S. mutans cell division leading to cell death. Use of CSP as a possible therapeutic agent is discussed. (C) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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