期刊
EXPERIMENTAL CELL RESEARCH
卷 310, 期 1, 页码 79-87出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2005.03.039
关键词
integrin; matrix metalloproteinase; collagen; contraction; HOS cells
Cell-matrix interactions transmit a wealth of information about the extracellular environment. In return, a variety of responses from the cell are initiated by changes in the matrix. One such response involves the positive regulation of matrix metalloproteinases (MMPs) by alpha(2)beta(1) integrin attaching to a specific extracellular matrix component, collagen. This study explores the relationship between mechanical and biochemical functions of alpha(2)beta(1) integrins as it pertains to regulating matrix remodeling. To understand this relationship, the individual influences of MMP activity and alpha(2)beta(1) integrin function on collagen gel contraction were studied. We have observed little evidence of mutual participation in matrix remodeling by the alpha(2)beta(1) integrin and MMP activity in cell models where alpha(2) is minimally expressed. In cells expressing high levels of alpha(2), we see an increase in gel contraction that is enhanced by MMP activity. Measuring tension as it builds within the gel reveals that alpha(2)beta(1) integrin presence correlates with force output but is insensitive to MMP activity. These data strongly suggest that alpha(2)beta(1) regulates collagen gel remodeling through multiple simultaneous mechanisms including force generation and modulation of MMP activity. (c) 2005 Elsevier Inc. All rights reserved.
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