期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 1, 页码 655-657出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01020-12
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资金
- British Society for Antimicrobial Chemotherapy
A Stenotrophomonas maltophilia mutant that coordinately hyper-expresses three resistance nodulation division-type efflux pump genes, smeZ, smeJ, and smeK, has been identified. SmeZ is responsible for elevating aminoglycoside MICs; SmeJ and SmeK are jointly responsible for elevating tetracycline, minocycline, and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate with this same phenotype was identified from a sample of six, and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.
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