期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 12, 页码 5469-5474出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05031-11
关键词
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资金
- NIH [1R43A1084295-01]
- HHMI
- [AI-R37 042347]
AvR2-V10.3 is an engineered R-type pyocin that specifically kills Escherichia coli O157, an enteric pathogen that is a major cause of food-borne diarrheal disease. New therapeutics to counteract E. coli O157 are needed, as currently available antibiotics can exacerbate the consequences of infection. We show here that orogastric administration of AvR2-V10.3 can prevent or ameliorate E. coli O157:H7-induced diarrhea and intestinal inflammation in an infant rabbit model of infection when the compound is administered either in a postexposure prophylactic regimen or after the onset of symptoms. Notably, administration of AvR2-V10.3 also reduces bacterial carriage and fecal shedding of this pathogen. Our findings support the further development of pathogen-specific R-type pyocins as a way to treat enteric infections.
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