期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 12, 页码 5952-5954出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05108-11
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A new variant of the New Delhi metallo-enzyme (NDM) carbapenemase was identified in a multidrug-resistant Escherichia coli ST648 isolate recovered from the perineum and throat of a patient in the United Kingdom with a recent history of hospitalization in India. NDM-5 differed from existing enzymes due to substitutions at positions 88 (Val -> Leu) and 154 (Met -> Leu) and reduced the susceptibility of E. coli TOP10 transformants to expanded-spectrum cephalosporins and carbapenems when expressed under its native promoter.
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