期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 6, 页码 3054-3057出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01516-10
关键词
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资金
- NIH [5 R01 AI072666-04]
The resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections occurring in CF patients.
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