期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 11, 页码 5399-5402出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00578-11
关键词
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资金
- Department of Homeland Security
- NIH [1R01 HL67984, 1R01 AI072666]
Antimicrobial peptides (AMPs) are integral components of innate immunity and are typically found in combinations in which they can synergize for broader-spectrum or more potent activity. Previously, we reported peptoid mimics of AMPs with potent and selective antimicrobial activity. Using checkerboard assays, we demonstrate that peptoids and AMPs can interact synergistically, with fractional inhibitory concentration indices as low as 0.16. These results strongly suggest that antimicrobial peptoids and peptides are functionally and mechanistically analogous.
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