期刊
CYTOKINE
卷 32, 期 2, 页码 81-84出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2005.07.012
关键词
multiple sclerosis; EAE; IL-10; regulatory T cells; tolerance
资金
- Medical Research Council [G0400768] Funding Source: Medline
- MRC [G0400768] Funding Source: UKRI
- Medical Research Council [G0400768] Funding Source: researchfish
Experimental autoimmune encephalomyelitis is the prototypic T cell-mediated autoimmune disease model. Classically, this disease was viewed in terms of type 1 versus type 2 immunity: the type 1 cytokines IFN gamma and TNF alpha promoting disease, whereas an IL-4-dominated, type 2 response was protective. However, studies in knockout mice do not support this paradigm. More recent data point to important roles for IL-23 and IL-17 (rather than IL-12 and IFN gamma) in the establishment and persistence of the inflammatory lesion. IL-10 appears to be the dominant cytokine mediating recovery. The source of IL-10 includes B cells (most probably in the peripheral lymphoid organs). However, the key IL-10-producing cell within the central nervous system is a CD4(+)CD25(+) T cell population that has regulatory function and is critical to resolution of the disease. (c) 2005 Elsevier Ltd. All rights reserved.
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