期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 6, 页码 2546-2551出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00022-11
关键词
-
资金
- INSERM, Paris, France [U914]
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, Paris, France
- European Community [HEALTH-2009-241742, HEALTH-F3-2008-223031]
Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified beta-lactamase OXA-163, differing from OXA-48 by a single amino substitution and a 4-amino-acid deletion. OXA-163 hydrolyzed penicillins, ceftazidime, and cefotaxime, whereas OXA-48 did not. However, OXA-163 had a much lower ability to hydrolyze carbapenems than OXA-48, therefore barely being considered a carbapenemase. In both isolates, the bla(OXA-163) gene was located on plasmids that differed in structure and size. However, a detailed genetic analysis revealed a similar genetic context in those isolates, with the bla(OXA-163) gene being bracketed by novel transposase genes, making this genetic environment different from that reported for the bla OXA-48 gene. This study identified the first class D beta-lactamase compromising both extended-spectrum cephalosporin and carbapenem activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据