期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1092, 期 1, 页码 114-124出版社
ELSEVIER
DOI: 10.1016/j.chroma.2005.06.089
关键词
adsorptive membranes; Aedes aegypti densonucleosis virus; ion exchange membrane; membrane chromatography
资金
- NIAID NIH HHS [AI 25489] Funding Source: Medline
Experimental and numerical results for binding Aedes aegypti densonucleosis virus (AeDNV) using anion and cation exchange membranes are presented. AeDNV particles are adsorbed by anion and cation exchange membranes providing the virus particles and membranes are oppositely charged. Q membranes which are strongly basic anion exchangers were the most effective. Dynamic and static capacities for Q membranes were found to be similar. A numerical model is proposed which assumes a log normal pore size distribution. By estimating the required parameters from static binding experiments, the model may be used to calculate the breakthrough curve for virus adsorption. (C) 2005 Elsevier B.V. All rights reserved.
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