期刊
SCIENCE
卷 310, 期 5747, 页码 496-498出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1113834
关键词
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资金
- NIGMS NIH HHS [R01 GM046383, R01 GM030179-24A1, R01 GM057063, R01 GM030179, R01 GM063702] Funding Source: Medline
- NIMH NIH HHS [R01 MH064801] Funding Source: Medline
Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and stow positive feedback loops creates a dual-time switch that is both rapidly inducible and resistant to noise in the upstream signaling system.
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