期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 5, 页码 2403-2405出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00082-11
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资金
- Palumed
- CNRS
- Agence Nationale pour la Recherche [ANR-08-MIEN-026-02]
Trioxaquine PA1259 is an efficient drug on larval-and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites.
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