Trioxaquine PA1259 Alkylates Heme in the Blood-Feeding Parasite Schistosoma mansoni

Trioxaquine PA1259 is an efficient drug on larval-and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites.