期刊
NEUROLOGY
卷 65, 期 8, 页码 1246-1252出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000180969.03719.81
关键词
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Objectives: To determine whether adults with persistent developmental stuttering (PDS) have auditory perceptual deficits. Methods: The authors compared the mismatch negativity (MMN) event-related brain potential elicited to simple tone ( frequency and duration) and phonetic contrasts in a sample of PDS subjects with that recorded in a sample of paired fluent control subjects. Results: Subjects with developmental stuttering had normal MMN to simple tone contrasts but a significant supratemporal left-lateralized enhancement of this electrophysiologic response to phonetic contrasts. In addition, the enhanced MMN correlated positively with speech disfluency as self-rated by the subjects. Conclusions: Individuals with persistent developmental stuttering have abnormal permanent traces for speech sounds, and their abnormal speech sound representation may underlie their speech disorder. The link between abnormal speech neural traces of the auditory cortex and speech disfluency supports the relevance of speech perception mechanisms to speech production.
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