期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 7, 页码 3594-3597出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01764-10
关键词
-
资金
- NIH [2R44AI052894-02]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- National Institute of Allergy and Infectious Diseases (NIAID)
- ARISTEIA (Excellence in Research Institutes of the Greek GSRT)
We compared the abilities of structurally related cationic cyclodextrins to inhibit Bacillus anthracis lethal toxin and Staphylococcus aureus alpha-hemolysin. We found that both beta- and gamma-cyclodextrin derivatives effectively inhibited anthrax toxin action by blocking the transmembrane oligomeric pores formed by the protective antigen (PA) subunit of the toxin, whereas alpha-cyclodextrins were ineffective. In contrast, alpha-hemolysin was selectively blocked only by beta-cyclodextrin derivatives, demonstrating that both symmetry and size of the inhibitor and the pore are important.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据