期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 56, 期 2, 页码 1135-1137出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05908-11
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资金
- AiCuris GmbH Co. KG
AIC246 (letermovir) is a potent anticytomegalovirus drug in clinical development. Here, we report a consistent antiviral efficacy of AIC246 against human cytomegalovirus laboratory strains, clinical isolates, and virus variants resistant to approved drugs. Furthermore, we describe a remarkable selectivity of AIC246 for human cytomegaloviruses compared to that of other alpha-, beta-, or gammaherpesviruses or nonrelated pathogenic viruses, including adeno-, hepadna-, retro-, orthomyxo-, and flaviviruses. Our data confirm and support an excellent and selective anticytomegaloviral activity of AIC246.
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