期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 56, 期 3, 页码 1584-1587出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05532-11
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TD-1792 is a new multivalent glycopeptide-cephalosporin antibiotic with potent activity against Gram-positive bacteria. The in vitro activity of TD-1792 was tested against 527 Staphylococcus aureus isolates, including multidrug-resistant isolates. TD-1792 was highly active against methicillin-susceptible S. aureus (MIC90, 0.015 mu g/ml), methicillin-resistant S. aureus, and heterogeneous vancomycin-intermediate S. aureus (MIC90, 0.03 mu g/ml). Time-kill studies demonstrated the potent bactericidal activity of TD-1792 at concentrations of <= 0.12 mu g/ml. A postantibiotic effect of >2 h was observed after exposure to TD-1792.
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