期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 8, 页码 3958-3960出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00417-10
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A G88C mutation in GyrA is one of the key alterations by which Mycobacterium tuberculosis mutants acquire DC-159a resistance in vitro. A novel double mutation in GyrA, G88C D94H, conferred high DC-159a resistance. Different mutation patterns in GyrA were demonstrated for DC-159a-resistant mutants and quinolone-resistant multidrug-resistant (QR-MDR) M. tuberculosis isolates, with a mutation either at position 90 or 94 and double mutations at 90 and 91 or at 90 and 94. DC-159a might be promising for QR M. tuberculosis treatment.
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