期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 9, 页码 3985-3989出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00590-11
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资金
- CDC
- USDA
- FDA Center for Veterinary Medicine (FDA-CVM)
Due to emerging resistance to traditional antimicrobial agents, such as ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol, azithromycin is increasingly used for the treatment of invasive Salmonella infections. In the present study, 696 isolates of non-Typhi Salmonella collected from humans, food animals, and retail meats in the United States were investigated for antimicrobial susceptibility to azithromycin. Seventy-two Salmonella enterica serotype Typhi isolates from humans were also tested. For each isolate, MICs of azithromycin and 15 other antimicrobial agents were determined by broth microdilution. Among the non-Typhi Salmonella isolates, azithromycin MICs among human isolates ranged from 1 to 32 mu g/ml, whereas the MICs among the animal and retail meat isolates ranged from 2 to 16 mu g/ml and 4 to 16 mu g/ml, respectively. Among Salmonella serotype Typhi isolates, the azithromycin MICs ranged from 4 to 16 mu g/ml. The highest MIC observed in the present study was 32 mu g/ml, and it was detected in three human isolates belonging to serotypes Kentucky, Montevideo, and Paratyphi A. Based on our findings, we propose an epidemiological cutoff value (ECOFF) for wild-type Salmonella of <= 16 mu g/ml of azithromycin. The susceptibility data provided could be used in combination with clinical outcome data to determine tentative clinical breakpoints for azithromycin and Salmonella enterica.
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