期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 11, 页码 5370-5373出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05202-11
关键词
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资金
- INSERM, France
- European Community [241742]
The carbapenemase gene bla(KPC), which is rapidly spreading worldwide, is located on a Tn3-based transposon, Tn4401. In a transposition-conjugation assay, Tn4401 was able to mobilize bla(KPC-2) gene at a frequency of 4.4 x 10(-6)/recipient cell. A 5-bp target site duplication was evidenced upon each insertion without target site specificity. This study demonstrated that Tn4401 is an active transposon capable of mobilizing bla(KPC) genes at high frequency.
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