期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 56, 期 2, 页码 765-769出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05231-11
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-
资金
- (National Center for Research Resources) through the Mississippi INBRE at The University of Southern Mississippi [P20RR016476]
Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 mu g/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 mu g/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin against Candida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.
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