期刊
SCIENCE
卷 310, 期 5748, 页码 644-648出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1117679
关键词
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资金
- NCI NIH HHS [5P30 CA46592, P50CA69568, R01 CA97063, UO1 CA111275-01] Funding Source: Medline
- NIA NIH HHS [R01AG21404] Funding Source: Medline
Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1. Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.
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