期刊
SCIENCE
卷 310, 期 5748, 页码 683-685出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1115524
关键词
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资金
- NIDA NIH HHS [K01 DA026504] Funding Source: Medline
Hypothalamic neurons that express neuropeptide Y (NPY) and agouti-related protein (AgRP) are thought to be critical regulators of feeding behavior and body weight. To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria toxin. Neonatal ablation of NPY/AgRP neurons had minimal effects on feeding, whereas their ablation in adults caused rapid starvation. These results suggest that network-based compensatory mechanisms can develop after the ablation of NPY/AgRP neurons in neonates but do not readily occur when these neurons become essential in adults.
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