期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 140, 期 1, 页码 55-62出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2005.05.011
关键词
diffusion tensor imaging; magnetic resonance imaging; fractional anisotropy; neuroimaging; neuronal degeneration
资金
- NIBIB NIH HHS [P41 EB015909] Funding Source: Medline
- NINDS NIH HHS [P01 NS16375] Funding Source: Medline
The pathology of Huntington's disease (HD) is characterized by diffuse brain atrophy, with the most substantial neuronal loss occurring in the caudate and putamen. Recent evidence suggests that there may be more widespread neuronal degeneration with significant involvement of extrastriate structures, including white matter. In this study of pre-symptomatic carriers of the HD genetic mutation, we have used diffusion tensor imaging to examine the integrity and organization of white matter in a group of individuals who previously demonstrated abnormalities in response to a functional magnetic resonance imaging paradigm. Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据