期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 2, 页码 913-916出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01362-10
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Asahi Glass Foundation
- Noda Institute for Scientific Research
- Institute for Fermentation, Osaka, Japan (IFO)
We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs.
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