Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients

Narcolepsy is a chronic sleep disorder. It is linked to the HLA-DQB]*0602 allele. A recent report established a genetic linkage between narcolepsy and the chromosomal region 4p13-q21 that contains the Clock gene. We studied two SNPs in the Clock gene aiming to find any association with narcolepsy. We did not find differences in genetic frequencies in the patients group. We concluded that these two SNPs are not associated with narcolepsy. (c) 2005 Elsevier B.V. All rights reserved.