期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 9, 页码 4003-4005出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00300-10
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资金
- KIT Start-Up-Budget of Applied Life Science
Antimicrobial peptides are promising novel peptide leads, but their low serum stability often limits their further consideration in drug development programs. Here, we describe a generally applicable strategy to stabilize peptides against serum proteases by replacing arginine residues with alpha-amino-3-guanidino-propionic acid (Agp). Peptide NH(2)-RRWRIVVIRVRR-CONH(2) was nearby totally degraded after 8 h in mouse serum, whereas the variant with Agp substituted was degraded less than 20%. The antimicrobial activity was not affected.
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