期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 12, 页码 5406-5412出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00580-10
关键词
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资金
- National Institutes of Health, National Center for Research Resources [1 R15 GM070562-01, P20 RR016480]
- ENMU
A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of Bacillus spp., Lactobacillus spp., and Listeria spp.
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