A column-based 'flush and flow' system for the asymmetric α-chlorination of acid halides

We describe a column based flow system in which a cinchona alkaloid based reagent/catalyst solid-phase promotes the asymmetric a-chlorination of acid chlorides to afford highly optically active alpha-chloroesters in high enantiomeric excess and in good yields. (c) 2005 Published by Elsevier Ltd.