4.7 Article

Carbon nanohorns as anticancer drug carriers

期刊

MOLECULAR PHARMACEUTICS
卷 2, 期 6, 页码 475-480

出版社

AMER CHEMICAL SOC
DOI: 10.1021/mp0500566

关键词

carbon nanotube; carbon nanohorn; anticancer drug; drug carrier; cisplatin

资金

  1. JSPS

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We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system.

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