期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 1, 页码 373-375出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01124-10
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资金
- Friedrich-Loeffler-Institut
A novel apramycin resistance gene, apmA, was detected on the ca.-40-kb resistance plasmid pAFS11 from bovine methicillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 (ST398). The apmA gene coded for a protein of 274 amino acids that was related only distantly to acetyltransferases involved in chloramphenicol or streptogramin A resistance. NsiI deletion of apmA resulted in a 16- to 32-fold decrease in the apramycin MICs. An apmA-specific PCR identified this gene in one additional bovine and four porcine MRSA ST398 isolates.
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