期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 2, 页码 940-942出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00995-10
关键词
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资金
- NIH NIDCR [R01 DE11367, R01 DE14161, RO1 DE017078]
The Candida albicans Upc2p transcription factor regulates ERG11, encoding the target of azole drugs. Gain-of-function mutations that contribute to resistance were recently identified in a series of sequential clinical isolates (N. Dunkel, T. T. Liu, K. S. Barker, R. Homayouni, J. Morschhauser, and P. D. Rogers, Eukaryot. Cell 7:1180-1190, 2008). In the present study, UPC2 was sequenced from a matched set of 17 isolates. An A643V substitution was present in all of the isolates in the series that overexpressed ERG11. Azole susceptibility, ergosterol levels, and expression of ERG genes were elevated in the A643V clinical isolates and in reconstructed strains.
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