期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 13, 期 21, 页码 5915-5920出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.07.050
关键词
Zanthoxylum ailanthoides; rutaceae; root bark; sesquiterpene; 10 beta-methoxymuurolan-4-en-3-one; 10 alpha-methoxycadinan-4-en-3-one; anti-HIV activity; secarine; gamma-fagarine; (+)-tembamide
资金
- NIAID NIH HHS [AI-33066] Funding Source: Medline
Two new sesquiterpenes, 10 beta-methoxymuurolan-4-en-3-one (1) and 10 alpha-methoxycadinan-4-en-3-one (2), were isolated from the root bark of Zanthoxylum ailanthoides. The structures of I and 2 were elucidated from spectroscopic data. Sixty-seven compounds obtained from the root bark of the same plant were evaluated for inhibition of HIV replication in H9 lymphocyte cells, and 14 compounds demonstrated significant activity. Among them, decarine, gamma-fagarine, and (+)-tembamide were the most potent anti-HIV compounds, with EC50 values of < 0.1 mu g/mL and TI values of > 226, > 231, and > 215, respectively, (c) 2005 Elsevier Ltd. All rights reserved.
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