期刊
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
卷 100, 期 5, 页码 579-581出版社
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1263/jbb.100.579
关键词
in situ exchange; recombinant Escherichia coli; human epidermal growth factor (hEGF) production; ion-exchange resin
A macroporous ion-exchange resin was adopted for the in situ exchange of acetic acid during human epidermal growth factor (hEGF) production by recombinant Escherichia coli JM101. The results of this study suggest that in situ exchange by macroporous resin can improve E. coli growth, decrease acetate accumulation and enhance hEGF production.
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