期刊
JOURNAL OF DENTAL RESEARCH
卷 84, 期 11, 页码 994-998出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910508401105
关键词
NF-kappa B; dental pulp stem cells; tumor necrosis factor; LPS; inflammation
资金
- NIDCR NIH HHS [R01 DE016513, R01 DE015973, R01 DE 016513, R01 DE 01593] Funding Source: Medline
Post-natal human dental pulp stem cells (DPSCs) represent a unique precursor population in the dental pulp, which has multipotential and can regenerate a dentin/pulp-like structure. Because the dental pulp is frequently infected by oral bacteria due to dental decay, in this study, we examined whether lipopolysaccharide (LPS) and tumor necrosis factor (TNF) activated the immunologic transcription factor nuclear factor kappa B (NF-kappa B) in DPSCs. We found that both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylation and degradation Of I kappa B alpha, resulting in the nuclear translocation of NF-kappa B. Consistently, both TNF and LPS rapidly induced the expression of the NF-kappa B-dependent gene interteukin-8 (IL-8). However, unlike in monocytes, we found that LPS could not induce the phosphorylation of the NF-kappa B active subunit p65 in DPSCs. In summary, our studies suggest that DPSCs may be involved in immune responses during pulpal infection through activating NF-kappa B.
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