期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 7, 页码 3011-3014出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00190-10
关键词
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资金
- NIH [AI073491]
- University of Minnesota Medical School
Bacterial resistance presents a difficult issue for fluoroquinolone treatment of bacterial infections. In previous work, we reported that 8-methoxy-quinazoline-2,4-diones are active against quinolone-resistant mutants of Escherichia coli. Here, we demonstrate the activity of a representative 8-methoxy-quinazoline-2,4-dione against quinolone-resistant gyrases. Furthermore, 8-methoxy-quinazoline-2,4-dione and other diones are shown to inhibit Staphylococcus aureus gyrase and topoisomerase IV with similar degrees of efficacy, suggesting that the diones might act as dual-targeting agents against S. aureus.
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