期刊
JOURNAL OF BACTERIOLOGY
卷 187, 期 22, 页码 7866-7869出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.187.22.7866-7869.2005
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资金
- NIDDK NIH HHS [DK44083, R01 DK044083, R37 DK044083] Funding Source: Medline
A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.
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