Topographically induced direct cell mechanotransduction

This review is designed to introduce the cytoskeleton and then discuss how mechanical forces may be transduced to the cell nucleus. In addition to this, it also tries to explain current thinking as to how the nucleus turns these mechanical cues into gene changes and is especially interested in mechanotransduction arising from topographically induced morphological changes, specifically nanotopography. Thus, this review also describes cell responses to topography. (c) 2005 IPEM. Published by Elsevier Ltd. All rights reserved.