期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 3, 页码 1293-1295出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00942-10
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资金
- French National Agency for Research on AIDS and Viral Hepatitis (Agence Nationale de Recherches sur le SIDA et les hepatites virales [ANRS])
- European Community [FP7/2007-2013, 223131]
We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.
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