期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 8, 页码 3524-3526出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01522-09
关键词
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资金
- National Science Foundation [DMR-0312046]
- Virginia Tech's Institute for Critical Technology and Applied Science
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [805179] Funding Source: National Science Foundation
Core-shell nanostructures with nonionic amphiphilic shells and ionic cores encapsulating gentamicin were designed for therapy against intracellular pathogens, including Salmonella and Listeria. Flow cytometry and confocal microscopy showed that their uptake into J774A.1 macrophages proceeded mainly by fluid-phase endocytosis and clathrin-mediated pathways. The nanostructures were nontoxic in vitro at doses of 50 to 250 mu g/ml, and they significantly reduced the amounts of intracellular Salmonella (0.53 log) and Listeria (3.16 log), thereby suggesting effective transport into the cells.
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