期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 6, 页码 2724-2727出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01674-09
关键词
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资金
- Spanish Network for Research on Infectious Diseases-REIPI [RD06/0008/0025, RD006/0008/0011]
- Fondo de Investigaciones Sanitarias [PI061368, PI081368, PS09/00687]
- SERGAS [PS07/90]
- Xunta de Galicia [07CSA050916PR]
- Xunta de Galicia
A clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a bla(OXA-24) gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the bla(OXA-24) gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.
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