期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 1, 页码 390-394出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00756-10
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Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum beta-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-beta-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 mu g/ml, including those with metallo-beta-lactamases.
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