期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 14, 期 11, 页码 1419-1434出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543784.14.11.1419
关键词
antiapoptotic; anti-inflammatory; antimalarial; antioxidant; antiproliferative; antitumour; Bcl-xL; BH3 mimetic; enzyme inhibition; gossypol; gossypol derivatives; HIV-1; natural product; psoriasis
Gossypol has received significant attention as a result of its potential therapeutic application as a male antifertility agent. Furthermore, recent research examining the biological activity of gossypol has revealed a number of other promising lines of enquiry. These have focused on the antitumour, antiviral and antioxidant actions of the compound in various disease states. This article provides an overview of the studies on the biological activity of gossypol, with particular attention paid to the mechanisms of its activity and its prospect as a medicinal product.
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