期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 8, 页码 3516-3519出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01756-09
关键词
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资金
- NIH [AI 070829, AI 062755]
- VA Merit Award
- VA Medical Research Service
Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the human antimicrobial peptide LL-37 induces the mefE promoter and confers resistance to erythromycin and LL-37. Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease.
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