期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 12, 页码 5275-5278出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01032-09
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- NIAID/NIH [HHSN272200700055C]
Following recent reports of ribosomal protein L3 mutations in laboratory-derived linezolid-resistant (LZDr) Staphylococcus aureus, we investigated whether similar mutations were present in LZDr staphylococci of clinical origin. Sequence analysis of a variety of LZDr isolates revealed two L3 mutations, Delta Ser145 (S. aureus NRS127) and Ala157Arg (Staphylococcus epidermidis 1653059), both occurring proximal to the oxazolidinone binding site in the peptidyl transferase center. The oxazolidinone torezolid maintained a >= 8-fold potency advantage over linezolid for both strains.
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