期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 7, 页码 3118-3121出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00183-09
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资金
- Protez Pharmaceuticals, Inc., Malvern, PA
Multistep and single-step resistance selection studies were performed with razupenem, linezolid, and vancomycin against 10 methicillin (meticillin)-resistant and -susceptible Staphylococcus aureus strains. After 20 daily subcultures, razupenem yielded only clones with MICs of > 4 mu g/ml in one strain (8 mu g/ml) whose parent's MIC was already 4 mu g/ml. After 18 to 49 passages in 6/10 strains, razupenem MICs rose from 0.016 to 2 mu g/ml (parents) to 0.125 to 8 mu g/ml (with clones stable after 10 drug-free subcultures). Single-step mutant selection frequencies were similarly low for razupenem and comparators.
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