期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 5, 页码 2133-2135出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01271-08
关键词
-
Using time-kill methodology, we investigated the interactions of an imipenem-colistin combination against 42 genetically distinct Klebsiella pneumoniae clinical isolates carrying a bla(VIM-1)-type gene. Irrespective of the imipenem MIC, the combination was synergistic (50%) or indifferent (50%) against colistin-susceptible strains, while it was antagonistic (55.6%) and rarely synergistic (11%) against non-colistin-susceptible strains (with synergy being observed only against strains with colistin MICs of 3 to 4 mu g/ml). The combination showed improved bactericidal activity against isolates susceptible either to both agents or to colistin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据