期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 4, 页码 1628-1629出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01624-08
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The fluconazole MIC distributions for Candida glabrata from testing 34 different clinical isolates and performing 51 tests on a single isolate mirrored each other. Since what is perceived as biological variation in isolates without resistance mechanisms is mainly methodological variation, breakpoints which divide this distribution not only lack a sound biological basis but also result in poor reproducibility of susceptibility characterization. This makes 2, 4, 8, and possibly 16 mu g/ml unsuitable breakpoints for C. glabrata and fluconazole.
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