期刊
CLINICA CHIMICA ACTA
卷 361, 期 1-2, 页码 206-210出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cccn.2005.05.024
关键词
genetic association studies; hepatitis C; lipid peroxidation; paraoxonase-1
Background: Hepatitis C virus infection is associated with hepatic free radical formation and enhanced lipid peroxidation and an individual's antioxidant status may play an important role. Paraoxonase-1 is an esterase that degrades oxidised lipids. In the present study, we investigated the genetic association of the most important paraoxonase-1 gene polymorphisms and the susceptibility to HCV-related chronic hepatitis. Methods: Paraoxonase-1 polymorphisms at positions -107, 55 and 192 were analysed from the genomic DNA of 186 patients and 386 healthy volunteers, as well as the serum concentration of total peroxides and standard biochemical tests. Results: Patients with chronic hepatitis had a higher frequency of the RR isoform of the 192 polymorphism than healthy subjects (13% vs. 7%, P<0.05). There were no significant differences with respect to the -107 and 55 polymorphisms. The plasma concentration of peroxides was higher in patients with chronic hepatitis [349.5 (246.2-479.8) vs. 115.4 (95.7-172.3) mu mol/L; P<0.001]. Conclusions: The present study suggests that the paraoxonase-1 192 polymorphism contributes, together with other polymorphisms, to the variations in the host response to HCV infection. (c) 2005 Elsevier B.V. All rights reserved.
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