期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 10, 页码 4556-4558出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00395-09
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- Deutsche Forschungsgemeinschaft (DFG) [WI2070/ 2-1]
Excision of staphylococcal cassette chromosome mec (SCCmec) is mediated through the ccrA- and -B-encoded recombinases. We investigated the effects of different antimicrobial agents on ccrA expression by using a ccrA::lacZ fusion and reverse transcription-PCR with methicillin (meticillin)-resistant Staphylococcus aureus strains MW2 (SCCmec IVa) and N315 (SCCmec II). Upregulation of ccrA was observed upon exposure to beta-lactam antibiotics. Vancomycin increased ccrA expression in MW2 but had no effect on N315. Vancomycin may contribute to the transfer of SCCmec IVa but have no effect in SCCmec II.
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